How does the recrudesce after breast cancer art do?

Think breast cancer is a kind of chronic illness at present, recrudescent move is the main reason that causes remedial failure. Jian hou mian of breast cancer art is the peak period that cancer has a relapse 3 years, endocrine cure has a relapse in prevention and cure very main effect has in move.

Think breast cancer is a kind of chronic illness at present, recrudescent move is the main reason that causes remedial failure. Jian hou mian of breast cancer art is the peak period that cancer has a relapse 3 years, endocrine cure has a relapse in prevention and cure very main effect has in move.

Medicaments prevents recrudescent curative effect because of the person different

Breast cancer is one kind depends on the tumour that hormone grows, the estrogen on estrogen and breast cancer cell suffers body union to be able to cause cancer cell proliferation. With as similar as estrogen element remedy (like amine of 3 benzene oxygen) close estrogen accepts put oneself in another's position, or pass decrease or the estrogen inside purify body, can prevent cancer cell proliferation, reduce tumor recrudesce thereby. This is the meaning that endocrine medications.

But, there is estrogen to accept put oneself in another's position on the cancer cell that is not patient of every breast cancer. The expression that hormone accepts put oneself in another's position follows the growth of the age and heighten, the rate of positive accepting put oneself in another's position of senile patient can amount to 80 ％ , and young patient may have 40 ％ only. In addition, the curative effect of endocrine cure still suffers with hormone related the positive rate of body, hormone suffers the patient curative effect of body strong positive to be able to be as high as 80% , and the patient curative effect that lacks estrogen to accept put oneself in another's position is less than 10 ％ .

Accordingly, the breast cancer patient that must notice only hormone suffers body positive just needs endocrine treatment. The patient that gets body negative to hormone does not recommend endocrine treatment commonly.

Whether menopause becomes watershed of the " that use drug "

The endocrine cure mechanism of breast cancer is block breaks estrogen to be opposite the stimulation of breast cancer cell. Can achieve this one goal through two kinds of methods: One, block breaks estrogen to accept put oneself in another's position, be like amine of 3 benzene oxygen. 2, those who reduce estrogen generate, the patient after menopause applies scent to change enzymatic depressor, the patient before menopause can carry an operation or medicaments is excised ovarian, can reduce the generation of estrogen. But ovarian castrate meets the patient before menopause create menopause artificially, symptom of the turn of life can appear on patient horse, affect life quality badly.

The strategy that the endocrine of breast cancer patient of menopause around treats is different, because the estrogen origin of menopause around female is different. The main source of estrogen of the female before menopause is ovarian, and ovarian function degrades after menopause, the main source of estrogen is androgen classics scent changes estrogen of enzymatic action translate into, scent changes enzymatic estrogen level to be able to drop accordingly.

The endocrine cure of the patient before · menopause is the most commonly used is profess to convinced amine of 3 benzene oxygen 5 years.

· if the patient will enter menopause, the proposal uses 2~3 of amine of 3 benzene oxygen first year, scent of the reoccupy after entering menopause changes enzymatic depressor, stop when 5 years completely likewise; Be like still not menopause, can continue to apply amine of 3 benzene oxygen to 5 years, right now if enter menopause, taller to recrudescent risk patient, but reoccupy scent changes enzymatic depressor 5 years to regard follow-up aggrandizement as cure, make whole period of treatment achieves 10 years.

The patient with very high risk has a relapse before · menopause, can consider an ovarian castrate, include an operation or medicaments excision is ovarian, use treatment of amine of 3 benzene oxygen at the same time.

· needs to notice, scent changes enzymatic depressor to disable to the patient before menopause, likely even and harmful, because the estrogen origin of these patients basically is ovarian, the scent of androgen of and rather than is changed.

The endocrine treatment of patient of cancer of the breast after menopause is more sophisticated. Is crucial, accord with following one of 4 conditions just can judge for menopause: One, bilateral after ovariotomy art. 2, the age is more than 60 years old. 3, 60 years old are not accepted below turn amine of oxygen of cure, 3 benzene, Tuoruimifen and the treatment that control ovarian function, stop naturally via 12 months above, and the level after hematic E2, FSH achieves menopause. 4, 60 years old accept the treatment such as amine of 3 benzene oxygen, Tuoruimifen below, hematic E2, FSH reachs the level after menopause, should detect for many times right now affirm.

Do not abandon using drug because of side-effect

Endocrine cure also can have a few side effect. Because of estrogen normal to keeping organism movement has main effect, the meeting when estrogen is too low causes osteoporosis, make a patient easy fracture; Circular respect can cause arteriosclerosis, thrombus embolism; Estrogen is too low still can cause atrophy of path of reproduction of secrete make water. The main side effect of amine of 3 benzene oxygen is the risk that increases cancer of the film inside the uterus and thrombus, and scent changes enzymatic depressor to be able to accentuate osteoporosis. But the side effect that must realize endocrine cure clearly, can reduce lacteal cancer recrudesce raise survival rate photograph to compare with its, can accept, at the same time the doctor also has corresponding method to reduce side effect. Accordingly, the side-effect that because worry about endocrine cure overly,does not answer and refuse endocrine treatment.