Tumor does a cell to be able to be restrained in inchoate growth phase

American scientist fights tumor the discovery after cell and normal dry cell undertake comparative recently, what tumor dry cell can be accepted put oneself in another's position in inchoate growth phase by a kind of albumen is unusual restrain.

Scientist of 　 　 United States fights tumor the discovery after cell and normal dry cell undertake comparative recently, what tumor dry cell can be accepted put oneself in another's position in inchoate growth phase by a kind of albumen is unusual restrain. This result promoted people greatly the understanding with physiological pathology of colloid to nerve tumour, and hopeful designs target of specific type cancer for future to the way with remedial method new open up. Relevant paper published on January 8, 2008 " cancer cell " (CancerCell) on the magazine.

　 　 tumour starts a cell (Tumor-initiatingcells, abbreviation TICs) it is the tumor cell that one fraction has dry cell quality, it and normal dry cell (NSCs) having a lot of common characteristics, ego duplicates and can split up for instance a large number of cancer cell. The research before this confirms, TICs consist in in the brain tumor of a variety of types, for instance tumour of colloid mother cell (Glioblastomas) . Although ten classification of TICs are like at NSCs, but they can appear special heredity is wrong, produce the sex that cause tumor thereby.

　 　 scientist has known, bone forms albumen (BMP) can mix according to growth phase microenvironment, the hyperplasia of adjusting control NSCs, become divided and wither die. But Dr. HowardA.Fine of institute of American national cancer expresses, "Up to now, report of very rare scientific research can confirm tumor works the development way that the cell splits up accurately, method of signal of which kinds of immanent dry cell works a cell to act well to tumor also is sealed greatly. Method of signal of which kinds of immanent dry cell works a cell to act well to tumor also is sealed greatly..

　 　 to solve this one problem better, fine and colleague from the mankind the depart in tumour of cell of initiative and colloid mother gives TICs, be in the NSCs of its and mankind and small rat each growth phase undertake contrasting study. The result makes clear, these TICs that go out from the depart inside system of grown cancer patient and terminal embryonic dry cell and adult do cellular photograph to compare, more adjacent do a cell at inchoate embryo. Researcher is special discovery, these TICs are in development is inchoate can be formed albumen to suffer body 1B partly at least by bone (BMPR1B) apparent is restrained, and the expression of BMPR1B is controlled complex system again by gene of a kind of Polycomb (PRC) adjusting control.

　 　 considers to confirm further, compulsive expression already the BMPR1B of silent " can let " the differentiation ability that these TICs return to normal, thereby the segmentation with farther block up, revulsive give final become divided.

　 　 Fine expresses, "New research result not only the understanding that does a cell to tumor to deepen the mankind levelled road, also let BMPR1B become the molecular drone of a kind of potential cure tumour at the same time. Also let BMPR1B become the molecular drone of a kind of potential cure tumour at the same time..