Cancer does cellular gene to convey as complex as transcribe matter

January 18 " molecular cell " (MolecularCell) go up the research that published 2 independence, the transcribe of a kind of polyhedral of will latter discovery is compound the function of content and control normal cell and cancer to do cellular gene to convey connection to rise.

　　 January 18 " molecular cell " (MolecularCell) go up the research that published 2 independence, the transcribe of a kind of polyhedral of will latter discovery is compound the function of content and control normal cell and cancer to do cellular gene to convey connection to rise. These research make we understood a kind to be guarded on evolution, as complex as transcribe adjustment matter contact is new-style inferior unit, the normal cell kernel that announced a kind to had not been described before suffers body to reach albumen of tumour of the MYC inside tumor cell the chromatin function that all active needs.

The starting need of process of 　 　 transcribe moves section factor to undertake nicety is coordinated complexly to a lot of differring. Co-activation factor is to have a variety of inferior the complex matter of the unit, they can be passed as enzymatic as RNA polymerization reach interaction of common transcribe factor and change transcribe course easily directly start, or will affect chromatin with indirect way. For example, move of form protein acetyl is enzymatic (HAT) the protein that complex matter is considered as what be linked together with chromatin through decorating to be called form protein will activation the process that gene conveys, and the function of form protein is the bobbin that is regarded as to let DNA twine.

The SAGA complex matter in microzyme of 　 　 consist in and its consist in are metazoan TFTC/STAGA of medium the content that be the same as a source (be called again HSAGA) all be the compound substance that contains HAT, its function is the contact that changes action to change common transcribe factor and DNA easily through the acetyl of form protein. Although HSAGA is considered as the content is the same as a source of the microzyme SAGA complex matter that has been studied adequately, but people is right its inferior the composition of the unit and function do not understand very. France the Dr.DidierDevys of genetics and element and cellular biology institute and its colleague affirmed Sitelasibao 3 new-style inferior unit: ATXN7L3, USP22 and ENY2. These inferior in unit and the complex matter of SAGA of consist in microzyme that had described once upon a time inferior the unit is the content that be the same as a source.

Researcher proves 　 　 , these are new affirm inferior the unit comes through synergism purify is odd element of incomplete radical extensive spends the extensive plain part in form protein H2B, this action and the in microzyme procedure that had described before are similar, but its are returned but purify is odd element of incomplete radical extensive changes form protein H2A medium extensive plain part. Hind a kind of got-up means is nonexistent in microzyme, but it compares sheet however in mammal the presence of H2B of element of incomplete radical extensive is more widespread. Important is, of drosophila TFTC/STAGA complex matter go floating element changes module to be the buildup with positional piebald effect child, it can defy different chromatin is silent. And the goes floating element changes module to suffer body be caused by for androgen complete transcribe activation of drosophila and mankind is needed. This one discovery has clinical sense, because, in prostate cancer, the active that androgen accepts put oneself in another's position often does not suffer adjust.

Dr.Devys says 　 　 : "In HSAGA complex matter, HAT and go floating element changes active both the correlation between put forward a kind of inviting mechanism, namely this kind of so called dialog between mark of specific group protein is to be in same adjust undertake harmony in complex matter. Must begin further research to detect to this mechanism these active and other chromatin decorate the related the whole story between complex matter, the event that just can understand these order happen so is how to participate in chromatin to reframe the process that reachs gene activation. The event that just can understand these order happen so is how to participate in chromatin to reframe the process that reachs gene activation..

In the research that 　 　 runs paralell at the same time in, hold Mass in the palm by Philadelphia? The group of the 2nd research that the Dr.StevenB.McMahon of university of outstanding Fei abdicate heads also affirmed a familial to USP22 is HSAGA. The cancerous dry cell that foregoing research had affirmed to USP22 is one kind has 11 gene labels partially, the patient that it can transfer those tumour finally accurately and tumour keep local the patient that turn distinguishs come. Dr.McMahon explanation says: "The other gene that with this kind of cancer dry cell labels is different, still undertake " of direct mechanism sex correlation without cancer of person general USP22 and mankind. The group of McMahon proves, the transcribe of mark target gene that activations by MYC tumour albumen needs USP22, and the function that the consume of USP22 will endanger MYC, include mammalian cell to change a process to will be damaged among them, reach the backwater that brings about cellular cycle.

The place on 　 　 put together is narrated, these results announced acetyl of HSAGA form protein to transfer enzymatic complex matter to also have the capacity that goes to form protein floating element is changed at the same time, soar greatly consequently entered people to be opposite the understanding of the mechanism of section of fine fine tuning of transcribe adjustment process. These discovery provided the new information with decisive people, the opportunity that decorates in the chromatin when controlling normal cell gene to convey namely and sequential importance, help people understand cancer to do cellular mark and HSAGA better inferior the biochemical function of unit USP22, affirm its are a kind of potential remedial mark target.