Does the expert explain why does the male contract liver cancer easily?

American Masschusetts Institute of Technology (MIT) newest research of the scientist makes clear, the male and female respond to the fundamental difference of means to chronic hepatitis, conduce to explain on gene level why the male suffers from more easily contract liver cancer.

Masschusetts Institute of Technology of 　 　 United States (MIT) newest research of the scientist makes clear, the male and female respond to the fundamental difference of means to chronic hepatitis, conduce to explain on gene level why the male suffers from more easily contract liver cancer. This is the scientist considers to be not cancer of progenitive sexual organs on gene level first difference of medium sex of male and female, relevant paper was published last year December " cancer studies " on periodical.

The liver of the male and female differs inherently, major difference begins to appear from adolescence, male liver gets in those days periodic growth the concussion with eruptive hormone, the gene expression that makes the male hepatic thereby has not at the female. This also explained why the male and female can appear to certain antibiotic and other remedy different reaction.

MIT studies the group passes the research discovery to mice, mighty mouse also has taller meet with to have rate of cancer of the liver. After mice is affected by liver screw bacterium, can arise with human second model reach the symptom with third same hepatitis.

No matter the mankind still is mice, healthy male and female can are opposite virulent make response with etc pressure. But male liver is lacked however cope with You Mou some the ability that infects the chronic inflammation that medium causes.

When male mice development goes chronic hepatitis, a few male are moved on hepatic gene and additionally a few are shut. In the meantime, certain female gene can activation again. The result appears one kind calls " liver sex maladjusted " (Liver-genderdisruption) gene expresses a fair amount of confidence. When researcher scale gives the atlas of sexual particularity gene, they discover this a collection of illustrative plates and inflammation way closely related. In the male that contracts chronic hepatitis, gene of particularity of certain sexual distinction can be conveyed excessive, and a few otherer convey inadequacy, liver cannot maintain normal metabolic function, at this moment animal of quite a few begins occurrence cancer.

Researcher puts forward, grown female gets not easily " liver sexual distinction is maladjusted the influence of " , she was not necessary to rely on activation instruction to maintain male gene to convey a collection of illustrative plates. Because female liver follows acquiescent development path, need is bigger disturb to just can start the program that cause cancer.

Researcher ever anticipated, if go up to sufferring from chronic hepatitis, but had not developed 1 year old of mice that become cancer to have deprive a theory, will rise to protect action. They still give mice infuse hormone of a kind of puissant male, will observe whether its can promote tumor development. Result, these two kinds of methods do not have be successful, this also proved male sex hormone, be like testosterone, can not promote rat to suffer from directly on cancer of the liver.

This discovery is right perhaps other organ cancer (like cancer of the stomach and colonic cancer) also have great sense, because of these diseases also with chronic inflammation somewhat associated, and very common in the male.