Scientist discovery can prevent the albumen that melanin tumour grows

When same gene mutation happens on two melanin cell, why to one among them stopped to grow and become relatively benign mole, and do another kind grow like out of control for malign melanin tumour cell?

　　 happens on two melanin cell when same gene mutation when, why to one among them stopped to grow and become relatively benign mole, and do another kind grow like out of control for malign melanin tumour cell? To explain this problem, the researcher of research center of medicine of Hughes of university of American haing Buddha was in a few days ago " cell " (Cell) announce on the magazine, they had discovered block breaks melanin tumour the gene of the tumour with this one malign very high rate learns the albumen that fundamental —— can prevent melanin tumour one kind to grow.

　 　 although mole is not a kind of tumour, but consider to discover at present, what the mistake exists in mole and melanin tumour is choppy, its are albumen of a kind of BRAF that be called as a result a medium amino acid produces a change. BRAF albumen grows in adjusting control and there is main effect in the signal access of differentiation. And this kind of mutation makes the active of BRAF albumen increases, quickened unusual hyperplasia then. In the melanin cell of mutation of a few existence, this kind of unusual become divided was not stopped, bring about the generation of melanin tumour then.

　 　 but for the melanin cell that produced BRAF gene mutation to some, they can enter persistent rest period, be called namely anile. These melanin cells became mole, is not melanin tumour.

The researcher MichaelGreen of research center of medicine of 　 　 Hughes method that searchs with gene whole series learned the albumen of the process to undertake searching to participating in this lifetime content. They use artificial complex to turn over transcribe virus to insert small RNA part to close extract of a certain gene in melanin cell gene. The some in these cells produced canceration, and some is done not have. Detected after extract of nearly 1000 gene, they discovered 17 useful gene part, the albumen that place of extract of these 17 gene codes is on the road that prevents melanin cell to be on canceration having main effect, among them 3 albumen are in anile or wither dies is very crucial in the process. A kind of among them albumen, namely insulin appearance grows 7(IGFBP7) of factor union albumen makes investigator people astonied. They discover, this kind of albumen that is secreted can not wait for the cell that secreting its in, and can release arrive at other cell as blood stream.

　 　 thinks before them, course of this one biology produces in interior of a cell merely. And this one new discovery makes they got very big inspire: If cell of a melanin begins the mutation of occurrence BRAF gene, so IGFBP7 of excretive of this cell place will enter the cell all round its, make a lot of cell dormancy or wither dies, is not the road that takes a risk to be on canceration. For this, investigator people fostered human melanin the cell of tumour recombined IGFBP7. The insect cell that recombines through reforming obtains this kind of albumen, its gene alignment and mankind are identical. When using this kind of protein at melanin tumour cell, they him wither dies, this also confirmed this kind of albumen further the action in antagonism tumour. Investigator also injects this kind of albumen to was turned to receive human melanin in the bandicoot blood of tumour, this kind of albumen enters tumor cell interior and the growth of tumor block is broken. Green says: The expression of albumen of this kind of decisive adjusting control in the melanin tumor that “ produces as a result of BRAF mutation was restrained, caused the canceration of these cells consequently. ”

Researcher expresses 　 　 , this thrash out this one domain all the time a problem of conflict: Is mole is fall asleep after all still the predecessor of melanin tumour? “ looks when you, they can suggest the patient excises mole normally, lest be put in the risk of canceration. ” but the research of Green does not think so however. Because IGFBP7 is a kind of albumen that is secreted, although one had produced the melanin cell of BRAF mutation to stop to secrete IGFBP7, excretive IGFBP7 still meets the cell kill its all round its. This is very powerful fight tumor mechanism.

The meaning that 　 　 studies this is the progress that stays in experimental domain not just, also provided a basis for the clinical cure henceforth likewise, IGFBP7 will make in the light of the action of systemic tumour cell its become treatment the step with melanin strong tumour.