The United States Luoqiesite university college of medicine (UniversityofRochester) the researcher that biology medicine genetics fastens uses green fluorescence discovery to already obtained affirmed cancer approach to act well as much in drosophila in the mankind and other animal, thereby open research and development of faster, lower cost is promoted natural a door that fights oxidation active compound.
United States Luoqiesite university college of medicine (UniversityofRochester) the researcher that biology medicine genetics fastens uses green fluorescence discovery to already obtained affirmed cancer approach to act well as much in drosophila in the mankind and other animal, thereby open research and development of faster, lower cost is promoted natural a door that fights oxidation active compound. The research achievement that this aids financially by academy of American national cancer is announced on January 15 " development cell " (DevelopmentalCell) on the magazine.
What heads this one research is DirkBohmann of professor of biology medicine genetics, he also is a genetics expert that studies drosophila, the hope can raise the goal of human health through studying drosophila is achieved. He expresses, "This is one of main mechanisms that antagonism of airframe in order to sends cancerous element, it enters help cell a kind of defence pattern that defies oxidation, medicaments development and experiment expend money and time relatively, this job will be aimed at the research and development of the new drug that prevents cancer quickly. This job will be aimed at the research and development of the new drug that prevents cancer quickly..
System of chemical signal is airframe is used at defence noxiousness attack, resembling is the main avenue when exhaust of cigarette flue gas, derv perhaps is faced with the menace with microbial danger. Consider to discover, one kind calls KEAP1 (member of partner of afterbirth oar albumen) gene can feel danger, release a NRF2, inside the cell that start fight oxidation active- - NRF2, namely nuclear cell fastens factor 2 relevant factor, it is the transcribe factor with a kind of reductive to oxidation sensitive response, can pass the expression to stimulative gene, come transcribe translates generation a few fight oxide, what different dissolves poison is enzymatic kind, with medicaments efficient outside platoon pump.
The person such as Dr. Bohmann and postdoctoral GerasimosP.Sykiotis developed the new method of way of NRF2 of a kind of research, the research of the way of signal of drosophila mode NRF2 that Sykiotis studies to school mode biology studies the group undertakes concerned human disease in Cantabrigian medicine Novartis now.
scientists already were mixed to consist in mankind, rodent the mechanism inside zebra fish body understands somewhat, because this Bohmann and Sykiotis hope to be able to be in,drosophila also can find relevant way in gene group, they discover one kind calls CNC (already studied discovery is used at deciding drosophila head development) gene and NRF2 action likeness, can be inside big range system of open cell defense.
This kind of defence includes activation sulfur oxygen returns albumen (Thioredoxins) turn with peptide of cereal Guang pleasant sulfur is enzymatic (GlutathioneS-transferases, abbreviation GSTs, it is to distributing extensively a group within mammalian, plant, avian, insect, helminth and microbial body muti_function be versed in together enzymatic) , these antioxidant can help a cell avoid the noxiousness in the environment and harmful element, but the antioxidant that sees with certain food and vitamin middling is different- - its action acts well temporarily only inside human body, bohman points out, the genetic change of the sex of a foundation that increases about NRF2 active is increase ceaselessly combat oxidation effect.
is in this research, bohmann and Sykiotis use gene project to let drosophila give out green fluorescence, when drosophila contains more and active CNC, can give out more dazzling fluorescence, helped researcher understand this one way to whether be activationed thereby, this kind of method is more convenient, more intuitionistic also.
Bohmann expresses, "Open our natural fight oxidation switch, to a lot of fighting cancer in research and development, or the big company of slow down consenescence, it is a good news. Same genetic mechanism is effective to a lot of biology, arrive from drosophila rodent animal, arrive again the mankind, we hope our tool can accelerate process of this one research and development, help more disease suffer from. Help more disease suffer from..
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