Large intestine cancerous element target the result to cure

On current ESMO conference, a lot of investigator reported target of concerned tumour element makes progress to the research that treats a field, now large intestine cancerous element target does one overview to remedial result.

On current ESMO conference, a lot of investigator reported target of concerned tumour element makes progress to the research that treats a field, now large intestine cancerous element target does one overview to remedial result.

Fight EGFR sheet

１ . The research that sheet of appropriate former times fights ｄ of B ｏ ｎ to wait on the west shows as a result, sheet of appropriate former times fights only drug on the west or combine Yi Li to replace Kang Zhi cure is epithelial grow factor accepts put oneself in another's position (EGFR) electropositive, Yi Li is replaced health be able to bear or endure terminal large intestine of medicine cancer, can reduce a patient to be replaced to Yi Li health be able to bear or endure medicine, raise survival rate. The report such as ｍ of ｅ of ｓ of C ｕ ｔ Ⅱ of a many center period clinical trial, jointly sheet of appropriate former times is fought on the west and FOLFOX4 plan a gleam of treats 43 EGFR positive to transfer sexual large intestine cancerous patient, always businesslike amount to 81 ％ , disease control rate amounts to 98 ％ , and relative safety.

2. Other fight EGFR sheet to fight ｂ of ａ of ｍ of ｕ of ｔ of ｉ of P ａ ｎ , EMD72000 and ｈ - R3 all change for person source fight EGFR sheet, half-life is longer. Clinical trial result shows a Ⅱ period, use ABX-EGF to combine IFL to treat EGFR positive to transfer sexual large intestine cancer, the patient is able to bear or endure suffer a gender good, and preliminary show clinical curative effect.

Depressor of acerbity kinase of ammonia of young member cheese

Depressor of acerbity kinase of ammonia of young member cheese (TKI ｓ ) also be one of heat that study at present, TKI ｓ includes reversibility (if Ji Fei replaces the Buddhist nun, dust collect for the Buddhist nun) and not reversibility (like EKB-569) two kinds of medicaments.

Sheet treats large intestine with TKI ｓ cancer is invalid, at present research all is to change cure jointly. Ji Fei combines FOLFOX4 to treat rambunctious terminal large intestine for the Buddhist nun cancer, businesslike for 23 ％ .

Additional, ｏ of ｎ of ｉ of ｐ of Z ａ ｍ reported a Ⅱ period is clinical test result, the positive of FOLFOX6 cure EGFR that simplifies jointly for the Buddhist nun with Ji Fei is terminal large intestine cancerous patient. Already entered at present group 37, in 25 patients that can evaluate curative effect, 20 effective, 4 stability, １ exemple makes progress. Same, dust collect rambunctious of cure of FOLFOX4 of the combination that replace the Buddhist nun is terminal large intestine cancer, businesslike achieve 23 ％ , disease control rate achieves 73 ％ .

ｔ of ｈ of ｃ of ｅ of ｒ of ｐ of F ｏ ｌ reported EKB-569 combines FOLFIRI plan a gleam of to treat progress period large intestine cancerous Ⅰ period the preliminary result of clinical trial, businesslike achieve 38 ％ , disease control rate achieves 85 ％ .

Divide into equal parts of ｄ of ｒ of ａ of ｗ of S ｔ ｅ and ｒ of ｅ of ｆ of ｅ of ｏ of ｈ of V ａ ｎ did not report combine FOLFOX4 with PTK ／ ZK respectively or the Ⅰ ／ that FOLFIRI plan regards large intestine of sex of move of cure of a gleam of as cancer Ⅱ period clinical trial, PTK ／ ZK is safe, be able to bear or endure it is better to suffer a gender, obtain preliminary and clinical curative effect. Two Ⅲ that combine FOLFOX4 period clinical trial is undertaking in.

SU5416 also is a kind of TKI, clinical trial combines two Ⅲ period respectively 5 - FU ／ CF and IFL a gleam of treat terminal large intestine cancer, clew cannot be lengthened live period.

Fight the odd clone antibody of VEGF

Sheet of shellfish cut down is fought (ｂ of ａ of ｍ of ｕ of ｚ of ｉ of ｃ of ａ of ｂｅ ｖ ) it is person source change fight antibody of VEGF Chan Kelong. Discover toward clinical trial already, sheet of shellfish cut down fights combination 5 - FU ／ CF treats terminal large intestine cancer, in businesslike, disease progress time is mixed live period respect all excel sheet is used 5 - the group changing cure of FU ／ CF.

ｒ of ａ of ｖ of ａ of ｎ of ｉ of ｂ of K ａ ｂ reported sheet of shellfish cut down fights combination 5 - FU ／ CF or sheet are used 5 - cure of FU ／ CF does not suit 209 times to accept according to establish the terminal large intestine that replaces health remedy cancerous patient. The result shows, sheet of shellfish cut down fights combination 5 - ／ CF can lengthen FU to live without disease significantly period, a gleam of that can regard terminal large intestine as cancer treats plan.

Sheet of shellfish cut down fights associated IFL a gleam of to treat terminal large intestine big sample book of cancer clinical trial also obtained Ⅲ period encouraging result. The report such as ｚ of ｔ of ｉ of ｗ of H ｕ ｒ , the 28 ～ after patient operation accepts sheet of shellfish cut down 60 days to refuse treatment, haemorrhage occurence rate does not increase significantly. Accordingly, it is better that sheet of shellfish cut down fights security.

Alternative COX-2 depressor

Stuff comes former times cloth is alternative COX-2 depressor, can make polyp of familial adenoma sex ill (FAP) patient polyp amount decreases, bulk decreases, already was approved to treat FAP by FDA.

The research that L ｉ ｎ has makes clear, stuff comes former times cloth and card earth up him bank associated application can reduce brothers to be asked for integratedly, can lengthen a disease progress time and live period. In addition, still have other COX-2 depressor (wait like cloth of Luo Fei former times) also entered clinical trial, have 4 big sample book at present clinical trial is in Ⅲ period the meaning in studying COX-2 depressor is assisting cure.